Vitamin B12, also known as Cobalamin,
is an essential vitamin required for the formation of red blood cells. It is
also responsible for maintaining the normal function of the brain and nervous
system. A deficiency in Vitamin B12 can
lead to the development of large immature red blood cells and subsequently,
megaloblastic anaemia. A relationship also exists between pernicious anaemia
and Vitamin B12 deficiency. Individuals deficient in Vitamin B12 may also
suffer from neurological and psychiatric abnormalities such as paraesthesias,
depression and dementia. In normal individuals, Vitamin B12 levels may be
anywhere between 200 - 900 pg/ml with values under 200pg/ml indicating
deficiency; signs of neurological deficiency or anaemia are usually evident in
patients with levels below 150pg/ml.
The Randox Acusera Level 1 Immunoassay
Premium, Immunoassay Premium Plus, and Liquid Immunoassay controls are among
the only controls on the market to contain sufficiently low enough levels of
Vitamin B12 (approx 150pg/ml), enabling the assessment of assay performance at
the clinical decision level, removing the need to purchase a separate Anaemia
control. If you cannot test the
sensitivity and performance of your method at clinically significant levels,
how can you be sure your patient results are correct? Randox Acusera Immunoassay
controls are supplied in three levels (which can be purchased either separately
or in a tri-level pack), allowing assay performance to be assessed throughout the
patient reportable range.
In addition to low Vitamin B12 levels,
the Randox Immunoassay Premium and Premium Plus controls also contain ultra low
levels of Ferritin and TSH as well as a wide range of other immunoassay
parameters allowing consolidation of fertility hormones, thyroid hormones,
kidney function tests, therapeutic drugs and other vitamins. In addition to this the Immunoassay Premium
Plus control also contains many of the routinely run
tumour markers including AFP, CA15-3,
CA19-9, CA-125, CEA, PSA and Free-PSA.
All Randox immunoassay controls are true third party
controls in that they are not designed for use with any particular reagent or
instrument manufacturer. They are highly stable and 100% human in origin,
meaning they will not be affected by changes to reagent batch.
For more information please visit
www.randox.com
or email marketing@randox.com.
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