Uniqsis has published details of a mild nitration method using its FlowSyn flow chemistry system that enables short reaction times and high conversion to be achieved whilst minimising the amount of corrosive (and potentially explosive) hot nitrating mixture present in the reactor at any one time.
Nitration is an important synthetic procedure that is often difficult to control. Under continuous flow-through conditions, however, exotherms are typically well controlled and nitration can be safely performed on a large scale. Using Uniqsis’s proprietary glass static mixer/reactor chip technology - nitration can be safely performed under accelerated conditions at elevated temperature and pressure without the associated problems typically encountered in batch reactors of controlling latency periods or controlling thermal run away...
Oxford Gene Technology (OGT), provider of innovative genetics research and biomarker solutions to advance molecular medicine, has produced a new, free-to-download whitepaper titled ‘When to use targeted resequencing — Choosing the right NGS method.’ The paper aims to assist researchers when planning NGS strategies by providing a detailed review of the major resequencing methods. Comparing and contrasting method suitability, the paper also examines the significant impact of data analysis, as well as time and cost considerations...
METTLER TOLEDO is pleased to present a new white paper to help those working in the Chemical, Food, Consumer Product, and Mineral industries meet the challenge of understanding, optimizing and controlling particle and droplet systems in a variety of applications including suspensions, emulsions and crystallizations.
“Best Practice for Inline Particle Size Characterization” reviews a series of real-life examples where prominent food, chemical and consumer product companies have used inline characterization methods to measure real time particle size dynamics at full-process concentration to ensure repeatable process endpoints, improve yield, and optimize product quality. Inconsistencies in solid or liquid dispersion, agglomeration or precipitation can create variability in product stability and manufacturing throughput...
Oxford Gene Technology (OGT), provider of innovative genetics research and biomarker solutions to advance molecular medicine, has produced a new, free-to-download application note on combined array comparative genomic hybridisation (aCGH) and single nucleotide polymorphism (SNP) arrays.
The application note, titled ‘Detecting copy number variants and runs of homozygosity on a single array — challenges and applications’ aims to support researchers in navigating this combined approach for the simultaneous detection of copy number variations (CNVs) and runs of homozygosity (ROH). aCGH has established itself as the “gold-standard” platform for array-based CNV detection. Recent advances have enabled the combination of aCGH probes for CNV detection with probes able to detect SNPs...
Drawing upon many years’ experience of designing and supplying liquid flowmeters to meet stringent OEM specifications - Titan Enterprises has produced an informative white paper 'How to specify liquid flowmeters'.
Accurate, reliable, cost effective flow measurement is more important today than it has ever been. However the optimal liquid flowmeter varies considerably according to a wide range of operational parameters including pipe bore, flow path, liquid viscosity, particulate levels, measurement accuracy, measurement dynamic range, maintenance and target purchase price...
Porvair Sciences has announced an application note describing the excellent results achievable from a new 96-well format version of its ChromaTrap chromatin immunoprecipitation (ChIP) assay technology.
Developments in the field of epigenetics are rapidly expanding as researchers elucidate the principles governing gene regulation through the in vivo dynamic binding of proteins to DNA. Key to this is the need to analyse large numbers of high and low abundant regulatory mechanisms to systematically map protein-DNA interactions following pathogen/disease stimulus...
New White Paper on Pipetting Ergonomics aims to protect researchers
Pipetting is a forceful and repetitive activity, and there is a strong association between pipetting and the occurrence of repetitive motion injuries. In fact, pipetting for just over an hour a day over the course of a year is enough to put researchers at risk, and the chances increase exponentially with workload and age. A new white paper about “The Ergonomics of Pipetting” has now been published by METTLER TOLEDO...
Temperature Control for Chemical Research and Production
Precise temperature control has a significant influence on performance and quality in chemical process engineering. The Unistat range of temperature control systems ensure accurate temperatures and stable process conditions in research laboratories, pilot plants and kilolabs worldwide. The new Unistat Hybrid technology offers solutions for temperature control of large scale production reactors,enabling an affordable, partial modernisation of existing central plant cooling/heating systems.
Genevac, world leaders in solvent removal technology, has over 20 year’s experience of supplying evaporators for removal of solvents from oil, fat and fuel samples.
Oils, fats and fuels are normally isolated from natural sources using extraction or separation techniques that present the final sample in a solution of organic solvent. Before analysis such samples must be dried or concentrated. Whether extracting and recovering additives, evaluating lipid content of foods, characterising reclaimed cooking oils before reprocessing / conversion to biofuels, or investigating drillling test samples - oils, fuels and fats can often prove difficult to dry without using very high temperatures which may lead to loss of the more volatile fractions within the sample....
Read MoreNew Opportunities in Cancer Research Created By Extracellular MatrixMar 7, 2013
A new white paper, available from AMSBIO, discusses the latest developments in extracellular matrix (ECM) and the opportunities they offer in cancer research
At least 80% of cancers are carcinomas, or tumours of the epithelia. Traditionally, cell transformation to a cancerous stage has been evaluated by anchorage dependent growth. More recently, the role of the extracellular matrix, already established in normal epithelial biology, has come to the fore in the study of carcinomas. The extracellular matrix is largely composed of several protein families, notably laminins, collagens and fibronectin. AMSBIO's new white paper focuses on ECM proteins most relevant to cancer research and their use in the oncology field...
Read MoreMerck Millipore Publishes White Paper: Effective In Vitro Bioanalytical Assays for Comparing Pharmacodynamics of Biosimilar Monoclonal AntibodiesMar 1, 2013
Merck Millipore, the Life Science division of Merck, today announced the publication of a white paper, "Effective In Vitro Bioanalytical Assays for Comparing Pharmacodynamics of Biosimilar Monoclonal Antibodies", which describes both regulatory and technical aspects of comparability studies for the development of biosimilars
Describes novel ligand-binding assays developed to streamline evaluation of biosimilars
Details use of flow cytometry and surface plasmon resonance to quantify binding of therapeutic monoclonal antibodies to molecules mediating cytotoxicity
Assays provide valuable preclinical data about drug properties and their physiological interactions without the need for animal experiments
Pipetting is a forceful and repetitive activity, and it is now widely accepted that there is a strong association between pipetting forces and the occurrence of developing Repetitive Strain Injuries (RSI's). In fact, pipetting for just over an hour a day over the course of a year is enough to put you at risk, and these risks tend to increase with workload and age. But for most scientists pipetting is an unavoidable daily task, so reducing or even preventing your risk of RSI should be high on your list of priorities. The best way to start protecting yourself is by ensuring you have all the correct facts and advice available about which conditions pose or increase your risk...
METTLER TOLEDO today announced the release of a white paper on the topic of gravimetric sample preparation. It compares the advantages and disadvantages of gravimetric vs. volumetric sample preparation methods, with particular reference to recognizing and acting to reduce errors associated with each step in the sample preparation workflow
Anyone working in a regulated analytical laboratory or a Quality Assurance (QA) / Quality Control (QC) environment will identify with the potentially costly and time-consuming process of investigating Out-of-Specification (OOS) results. More than 50% of OOS results in analytical workflows are reportedly caused by sample processing and operator errors. Implementing automated Gravimetric Sample Preparation and following Good Weighing Practice™ (GWP®) can help reduce data variability and OOS results.
Read MoreNew Olympus Life Science Microscopy website and QR code system offers intuitive, application-focused navigationDec 6, 2012
Interactive media for targeted and fast information access
As part of its promise to provide world-class service, Olympus has enhanced its website to guarantee comprehensive, accessible and tailored support for all customers. Based on extensive market research and customer feedback, Olympus completely redesigned its website for life science microscopy. It now offers customers an interactive resource, enabling them to navigate in an application-focused manner towards the products and services that are best suited for their individual requirements...
Read MoreNew Whitepaper Compares Gene Expression Analysis TechnologiesNov 22, 2012
Plexpress helps researchers to make an informed choice
Plexpress, developer of the innovative TRAC platform for high-throughput gene expression analysis, has released a free-to-download whitepaper entitled “Gene expression analysis: A review – high throughput multiplex gene expression analysis from discovery to in-depth investigation”. The document provides a comprehensive review of the major methods available, comparing and contrasting the various...
Read MoreMalvern Instruments introduces DLS MicrorheologyOct 10, 2012
New Zetasizer Nano ZSP offers emerging rheology technique for weakly structured fluids
With the recent launch of the new top of the range Zetasizer Nano ZSP system, Malvern Instruments has added dynamic light scattering (DLS) Microrheology to its portfolio of materials characterization techniques. To introduce this powerful technique, the company has published an in-depth paper that explains the background to microrheology, and how it can be used to investigate the rheological properties of even the most weakly structured fluids, using sample volumes on the microliter scale. ‘An Introduction to DLS Microrheology’ includes data for protein (bovine serum albumin (BSA)) and polyethylene oxide (PEO) solutions that illustrate the significance and usefulness of the method. It is freely available from the Malvern website.
As science evolves, new technologies and methods are continuously created that supplant older, outdated methods. The main reasons to replace outdated applications are: to save money, to save time, and to be safer. If a new application can do all three, its chance of successfully replacing an older technology greatly increases
In the last decade, the microplate reader has become a multi-mode, multi-functional instrument that is used routinely in most laboratories. As such, the number and type of microplate based applications have grown tremendously. A number of these applications use the Fluorescence Intensity, Fluorescence Polarization or Time-Resolved Fluorescence detection mode in a microplate reader....
Read More'Ethanol Production by Dry Milling' - New Case Study from Cole ParmerAug 20, 2012 Cole-Parmer's Masterflex® provides accurate and repeatable pumping solution for ethanol production process, enabling precise volume of enzymes to be added continuously.
Ethanol is a versatile alcohol that is used in fuel, beverages and thermometers. Two processes utilized to produce ethanol from grain are dry milling and wet milling. Dry milling plants generate ethanol, carbon dioxide, and distillers' grain, which is used as a high-protein livestock feed supplement. Wet milling plants create these and additional valuable byproducts such as corn syrup, dextrose, and fructose, however they cost substantially more to build and operate than a dry milling plant...
Read MoreMalvern Spraytec used in characterizing agricultural spray nozzlesAug 20, 2012A new application note from Malvern Instruments discusses the importance of droplet size in agricultural spraying and describes the use of the company's Spraytec system in defining the performance of agrochemical application systems.
‘Characterization of agricultural spray nozzles using the Malvern Spraytec' provides insight into the way this laser diffraction droplet size analyzer helps in understanding the performance of spray nozzles used for the application of herbicides, fungicides and insecticides.
Read MoreImproved cryopreservation of human hepatocytesAug 13, 2012A recently published article from researchers at the Karolinska Institute details an improved protocol for cryopreservation of primary human hepatocyte using STEM-CELLBANKER® cryopreservation solution from AMSBIO.
In the article the authors compare cryopreservation of liver hepatocytes using STEM-CELLBANKER with the frequently used DMSO-University of Wisconsin (DMSO-UW) medium protocol. Both protocols yielded hepatocytes with good P450 function, however, the STEM-CELLBANKER protocol gave a higher viability than the DMSO-UW cryoprotectant. The researchers concluded that STEM-CELLBANKER beneficially is also xeno-free and will be applicable to cryopreservation of clinical-grade primary human hepatocytes...
Read MoreOn-demand webinar discusses latest advances in 3D Cell Culture technologyJul 17, 2012AMSBIO, a supplier of advanced 3D tools to the life science community, recently participated in a '3D Cell Culture in Drug Discovery and Disease Modeling' webinar. Due to huge demand, the webinar which aired on 22nd May, has been reproduced in an on-demand version.
Driven by the limitations of 2D cell cultures - scientists search for alternative solutions that mirror the environment experienced by normal cells in the body and replicate complex tissue structures and in vivo-like morphology. The '3D Cell Culture in Drug Discovery and Disease Modeling' webinar focuses on discussing the latest advances in 3D technology and its contribution to conducting more realistic research...
Read More
“Best Practice for Inline Particle Size Characterization” reviews a series of real-life examples where prominent food, chemical and consumer product companies have used inline characterization methods to measure real time particle size dynamics at full-process concentration to ensure repeatable process endpoints, improve yield, and optimize product quality. Inconsistencies in solid or liquid dispersion, agglomeration or precipitation can create variability in product stability and manufacturing throughput...
Accurate, reliable, cost effective flow measurement is more important today than it has ever been. However the optimal liquid flowmeter varies considerably according to a wide range of operational parameters including pipe bore, flow path, liquid viscosity, particulate levels, measurement accuracy, measurement dynamic range, maintenance and target purchase price...
Developments in the field of epigenetics are rapidly expanding as researchers elucidate the principles governing gene regulation through the in vivo dynamic binding of proteins to DNA. Key to this is the need to analyse large numbers of high and low abundant regulatory mechanisms to systematically map protein-DNA interactions following pathogen/disease stimulus...
Pipetting is a forceful and repetitive activity, and there is a strong association between pipetting and the occurrence of repetitive motion injuries. In fact, pipetting for just over an hour a day over the course of a year is enough to put researchers at risk, and the chances increase exponentially with workload and age. 
Precise temperature control has a significant influence on performance and quality in chemical process engineering. The Unistat range of temperature control systems ensure accurate temperatures and stable process conditions in research laboratories, pilot plants and kilolabs worldwide. The new Unistat Hybrid technology offers solutions for temperature control of large scale production reactors,enabling an affordable, partial modernisation of existing central plant cooling/heating systems.
While the first one describes the determination of sodium for the manufacture of margarine, the second one describes the determination of sodium in soy milk.....
Oils, fats and fuels are normally isolated from natural sources using extraction or separation techniques that present the final sample in a solution of organic solvent. Before analysis such samples must be dried or concentrated. Whether extracting and recovering additives, evaluating lipid content of foods, characterising reclaimed cooking oils before reprocessing / conversion to biofuels, or investigating drillling test samples - oils, fuels and fats can often prove difficult to dry without using very high temperatures which may lead to loss of the more volatile fractions within the sample....
Describes novel ligand-binding assays developed to streamline evaluation of biosimilars
Anyone working in a regulated analytical laboratory or a Quality Assurance (QA) / Quality Control (QC) environment will identify with the potentially costly and time-consuming process of investigating Out-of-Specification (OOS) results. More than 50% of OOS results in analytical workflows are reportedly caused by sample processing and operator errors. Implementing automated Gravimetric Sample Preparation and following Good Weighing Practice™ (GWP®) can help reduce data variability and OOS results.
As part of its promise to provide world-class service, Olympus has enhanced its website to guarantee comprehensive, accessible and tailored support for all customers. Based on extensive market research and customer feedback, Olympus completely redesigned its website for life science microscopy. It now offers customers an interactive resource, enabling them to navigate in an application-focused manner towards the products and services that are best suited for their individual requirements...
Plexpress, developer of the innovative TRAC platform for high-throughput gene expression analysis, has released a free-to-download whitepaper entitled “Gene expression analysis: A review – high throughput multiplex gene expression analysis from discovery to in-depth investigation”. The document provides a comprehensive review of the major methods available, comparing and contrasting the various...
With the recent launch of the new top of the range Zetasizer Nano ZSP system, Malvern Instruments has added dynamic light scattering (DLS) Microrheology to its portfolio of materials characterization techniques. To introduce this powerful technique, the company has published an in-depth paper that explains the background to microrheology, and how it can be used to investigate the rheological properties of even the most weakly structured fluids, using sample volumes on the microliter scale. ‘An Introduction to DLS Microrheology’ includes data for protein (bovine serum albumin (BSA)) and polyethylene oxide (PEO) solutions that illustrate the significance and usefulness of the method. It is freely available from the Malvern website.
In the last decade, the microplate reader has become a multi-mode, multi-functional instrument that is used routinely in most laboratories. As such, the number and type of microplate based applications have grown tremendously. A number of these applications use the Fluorescence Intensity, Fluorescence Polarization or Time-Resolved Fluorescence detection mode in a microplate reader....
Ethanol is a versatile alcohol that is used in fuel, beverages and thermometers. Two processes utilized to produce ethanol from grain are dry milling and wet milling. Dry milling plants generate ethanol, carbon dioxide, and distillers' grain, which is used as a high-protein livestock feed supplement. Wet milling plants create these and additional valuable byproducts such as corn syrup, dextrose, and fructose, however they cost substantially more to build and operate than a dry milling plant...
‘Characterization of agricultural spray nozzles using the Malvern Spraytec' provides insight into the way this laser diffraction droplet size analyzer helps in understanding the performance of spray nozzles used for the application of herbicides, fungicides and insecticides.
In the article the authors compare cryopreservation of liver hepatocytes using STEM-CELLBANKER with the frequently used DMSO-University of Wisconsin (DMSO-UW) medium protocol. Both protocols yielded hepatocytes with good P450 function, however, the STEM-CELLBANKER protocol gave a higher viability than the DMSO-UW cryoprotectant. The researchers concluded that STEM-CELLBANKER beneficially is also xeno-free and will be applicable to cryopreservation of clinical-grade primary human hepatocytes...
Driven by the limitations of 2D cell cultures - scientists search for alternative solutions that mirror the environment experienced by normal cells in the body and replicate complex tissue structures and in vivo-like morphology. The '3D Cell Culture in Drug Discovery and Disease Modeling' webinar focuses on discussing the latest advances in 3D technology and its contribution to conducting more realistic research...