Exactive
Plus System Sets New Standards in Speed and Resolving Power for High-Throughput
Screening, Identification and Quantification of Compounds in Complex Matrices
Thermo Fisher Scientific Inc., the
world leader in serving science, today announced the Thermo Scientific Exactive
Plus system, the company's latest benchtop liquid chromatography-mass
spectrometry (LC-MS) system for high-throughput screening, identification and
quantification of compounds in complex matrices. Powered by Thermo Scientific
Orbitrap technology, the standard in full-scan, high-resolution accurate-mass
(HR/AM) measurement, the Exactive
TM Plus system extends the
capabilities of the Exactive system with advanced signal processing, ion optics
and transmission technologies. It features full field upgradeability to the
Thermo Scientific Q Exactive high-performance quadrupole-Orbitrap LC-MS/MS
system.
The company will
showcase the new Exactive Plus system within Thermo Scientific booth 1 and its
hospitality suite at the Vancouver Convention Center (Parkview Terrace - Rooms
1, 2 and 3) during ASMS 2012, being held from May 20 - 24.
Like its predecessor, the Exactive Plus system produces full-scan HR/AM
data, minimizing tedious MS method development and allowing retrospective data
analysis. The Exactive Plus system is easy to use, cost-effective to operate
and, when coupled with workflow-driven software, is an ideal instrument for
routine analytical laboratories. The system has a range of applications, including
food safety, environmental, forensic toxicology, drug metabolism/pharmacokinetics
(DMPK) research and intact antibody analyses.
Advanced signal
processing increases system scan speed by a factor of two, providing ultra-high
mass resolution to resolve components in complex sample matrices. With fast
scanning, the Exactive Plus system ensures exact mass measurement for
applications involving UHPLC. Fast scanning also
enables fast polarity switching without sacrificing mass accuracy. Brighter ion
source optics and improved C-Trap-to-HCD cell transmission enhance sensitivity
and improve low-mass ion transmission.
"When analyzing
complex sample matrices such as food, LC-MS speed
and resolving power play a critical role in determining analysis times and confidence
in results," said Ian Jardine, vice president and chief
technology officer for LS-MS at Thermo Fisher. "With
compelling increases in scanning speed and resolving power, the Exactive Plus system offers customers performing a broad range of Qual/Quan workflows significant
enhancements in sample throughput and quality of results."
Notable features of the
Exactive Plus system include:
- Ultra-high resolving power (up to 140,000
FWHM) that provides precise mass accuracy for complex sample analysis.
- Mass accuracy of better than 1 ppm in full
scan and all-ion-fragmentation (AIF) modes using fully automated AGC and
mass calibration procedures.
- Fast scanning speed (frequency) up to 12 Hz,
which ensures exact-mass measurements fully compatible with fast chromatography
technology such as UHPLC.
- Fast polarity switching without sacrificing
mass accuracy in any scan; a full cycle of 1 positive and 1 negative scan
performed in 1 second, at a resolution setting of
35,000.
- All-ion-fragmentation (AIF) with multiple
dissociation techniques, in-source collisional induced dissociation (CID)
and optional higher energy collisional dissociation (HCD) which provide MS
and MS/MS data to deliver increased structural
information.
- Extended mass
range of 50 - 6,000 m/z for improved analysis of intact proteins and
singly charged ions.
- Fully upgradeable to the Q ExactiveTM
high-performance quadrupole-OrbitrapTM LC-MS/MS system for budgetary and
analytical flexibility.
- Powerful
software: ExactFinder 2.0 to streamline food, environmental and forensic
tox workflows; MetQuest 1.2 to speed quan/qual analysis of drugs and
metabolites; and SIEVE 2.0 to streamline differential expression analysis
of proteins, peptides and metabolites.
Extended mass range and improved polarity
switching will now be standard features of the Q Exactive as well.
For more information about the new Thermo
Scientific Exactive Plus system, please visit Thermo Scientific booth 1 or its hospitality
suite at ASMS 2012. Alternatively, please call (800) 532-4752, e-mail
analyze@thermo.com or visit
www.thermoscientific.com/exactiveplus.
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