Thermo Fisher Scientific Inc.,
the world leader in serving science, today announced that the University of
Dublin has purchased the Maybridge Ro3 Diversity Fragment library for use in a
new drug discovery program. As an institution known for its world-class
biomedical research, the University is the first organization in the Republic
of Ireland to undertake a fragment-based screening programme. With possible
applications in the fight against viral replication, bacterial infections and
Alzheimer's disease, this research has the potential to provide significant
therapeutic advances.
Dr. Neil Ferguson's team - the
UCD Biomolecular Interactions Group - combines state-of-the-art biophysical and
structural biology methodologies to unravel the molecular structures and forces
that cause human diseases. By incorporating the Maybridge Ro3 library into his
existing multi-disciplinary approach, Dr. Ferguson adds a new dimension to his
team's research and their ability to identify potential drug compounds. The Ro3
library will enable the team to pursue challenging targets (such as those
incompatible with conventional HTS programmes), neglected diseases and, in many
cases, new targets emerging from his basic research programmes.
"Combining the power of
fragment-based drug discovery with our high-end instrumentation, we can
effectively tackle our ever-expanding portfolio of therapeutic targets," said
Dr. Ferguson. "Our aim is to identify novel leads that can develop into
next-generation therapeutics. I gave long and serious consideration to the
fragment library that we would use for this new initiative. Among the key
criteria were the chemical diversity, validated solubility profiles and a
proven track record in hit identification. The ready availability of its
components in bulk format and their superior stability also makes the Maybridge
Ro3 library an excellent choice for further development of the downstream
medicinal chemistry."
Dr. Ferguson concluded, "We feel
that our current skill set, therapeutic targets, biophysical infrastructure and
the Maybridge Ro3 library all place us well to make a serious fragment-based
drug discovery effort within the academic sphere - watch this space!"
The Maybridge Ro3 Diversity
Fragment library is a resource of more than 1500, hand-selected, compound
fragments and small molecule pharmacophores. Selection criteria include the
compliance with the "Rule of Three" (Ro3) for lead generation and for the
superior solubility profile of the compound. This highly diverse fragment
library is available as three 500-compound sets; each compound in the library
is pre-solubilised as a 1 mL, 10 mM solution, providing 10 µMol of 95 percent
purity material dissolved in analytical grade DMSO.
For further information on this product
please visit
www.maybridge.com.
About Maybridge Products
The
Maybridge product line, part of Thermo Fisher Scientific, features highly
innovative drug-like molecules and screening compounds for drug discovery and
development. Available for both lab and development scale, the offering
continually expands with the production of novel heterocyclic and phenyl
ring-based chemical building blocks, including a unique and growing range of
reactive intermediates. For more information about Maybridge brand products
visit
www.maybridge.com or call +44 18
40 77 05 67.
About
Thermo Fisher Scientific
Thermo Fisher Scientific Inc. (NYSE: TMO) is
the world leader in serving science. Our mission is to enable our customers to
make the world healthier, cleaner and safer. With revenues of nearly $11
billion, we have approximately 37,000 employees and serve customers within
pharmaceutical and biotech companies, hospitals and clinical diagnostic labs,
universities, research institutions and government agencies, as well as in
environmental and process control industries. We create value for our key
stakeholders through two premier brands, Thermo Scientific and Fisher
Scientific, which offer a unique combination of continuous technology
development and the most convenient purchasing options. Our products and
services help accelerate the pace of scientific discovery, and solve analytical
challenges ranging from complex research to routine testing to field
applications. Visit
www.thermofisher.com.
Subscribe to any of our newsletters for the latest on new laboratory products, industry news, case studies and much more!
Request your free copies HERE
Popular this Month
Top 10 most popular articles this month
Today's Picks
Looking for a Supplier?
Search by company or by product
Please note Lab Bulletin does not sell, supply any of the products featured on this website. If you have an enquiry, please use the contact form below the article or company profile and we will send your request to the supplier so that they can contact you directly.
Lab Bulletin is published by newleaf marketing communications ltd.