Sera Lab launches extensive microsome and S9 fraction range for drug metabolism studies

SeralabSera Laboratories International Ltd (Sera Lab), the serum specialist, has launched a comprehensive range of liver microsome products from over 12 species, including mouse, rabbit, monkey and chicken. Researchers can select from pure microsomes or S9 fractions, and animal liver cytosol is also available. In order to facilitate requirements recommended by REACH, Sera Lab is also able to supply bespoke microsome products from other species or strains, as required. Each product is accompanied by a Certificate of Analysis.  

Microsomes are a valuable tool for investigating drugs metabolism (enzyme inhibition, clearance and metabolite identification), as well as for examining in vitro drug-drug interactions. They are produced by mechanically homogenising cells such that the endoplasmic reticulum is fragmented, the fractions of which reform into microsomes, which are subsequently collected from the cell remnants via differential centrifugation. During this process, the numerous different phase I cytochrome P450 enzymes (CYPs) are concentrated within the microsomes. The S9 fraction contains microscomes as well as cytosolic phase II metabolism-related enzymes.  

With this extensive portfolio of microsomes and S9 fractions, as well as the capability to provide bespoke products, Sera Lab offers researchers the opportunity to match the species, strain and enzyme activity requirements for successful drug metabolism studies. 

For further information, please visit www.seralab.co.uk


If you have not logged into the website then please enter your details below.



 

Subscribe to any of our newsletters for the latest on new laboratory products, industry news, case studies and much more!

Newsletters from Lab Bulletin

 

Request your free copies HERE

 

 

 

Popular this Month

Top 10 most popular articles this month

 

 

Today's Picks

 


 

Looking for a Supplier?

Search by company or by product

 


Company Name:

Product:


 

 

 

 

Please note Lab Bulletin does not sell, supply any of the products featured on this website. If you have an enquiry, please use the contact form below the article or company profile and we will send your request to the supplier so that they can contact you directly.

Lab Bulletin is published by newleaf marketing communications ltd.