Polishing in antibody production is usually
performed on quaternary ammonium (Q) membranes in flow-through mode, since the
overall speed and productivity is much higher than on traditional
anion-exchange columns. However, the binding capacity of Q ligands is reduced
at higher conductivities, so concentrated feed streams must be diluted to
adequately remove contaminants such as DNA, host cell proteins, viruses and
endotoxins.
Sartobind STIC PA (primary amine)
anion-exchange membrane overcomes this limitation and binds contaminants at
high conductivities under high-salt conditions at up to 20 mS/cm. The
salt-tolerant anion exchanger can directly process cation-exchange pools
without further dilution. Buffer consumption and buffer tank investments can be
reduced.
Sartobind pico with 0.08 ml is the latest
member of the Sartobind STIC family with nano, 5", 10", 30" and mega capsules.
Since all devices are used for flow-through polishing, a 4 mm bed height is
kept constant to scale to larger devices up to 1.6 liters. The small membrane
volume of 0.08 ml reduces material consumption during testing and virus spiking
studies to save cost during the initial development phases.
All membrane adsorber capsules are "plug and
play" devices and can be used like filters. As the materials are disposed of
after a single use, this saves validation costs.
For further information
click here
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