Two new papers are going to press featuring the
use of Anasys Instruments' nanoIR
TM system by Professor Lynne S. Taylor's group
in the Department of Industrial and Physical Pharmacy at Purdue University. In
each study, miscibility of pharmaceutically relevant blends was examined and
specific sub-micrometer-sized domains characterized using standard atomic force
microscopy (AFM) and nanoscale Infrared spectroscopy (AFM-IR).
The first of the two papers, entitled "Nanoscale Mid-Infrared Imaging of
Phase Separation in a Drug-Polymer Blend" is being published in the June
2012 issue of the
Journal of Pharmaceutical Sciences. The researchers
at Purdue explored the applicability of nanoscale IR spectroscopy and imaging
to analyze a partially miscible model pharmaceutical drug-polymer system
consisting of felodipine and poly(acrylic acid) (PAA). By combining AFM
topography imaging with AFM-IR chemical information obtained at a high spatial
resolution, it was possible to interrogate both the structure and chemical
composition of phases in the felodipine-PAA blends.
The second of the papers "Nanoscale Mid-Infrared Evaluation of the
Miscibility Behavior of Blends of Dextran or Maltodextrin with
Poly(vinylpyrrolidone)" has been accepted for publication in the
Journal
of Molecular Pharmaceuticals. In this study, the AFM topography data
combined with AFM-IR chemical information provided structural insights into the
formation of phase-separated systems. The size, shape, and distribution of the
different domains formed and the dependence of these features on the molecular
weights of the polymers was analyzed. AFM-IR analysis is an important
complement to more traditional miscibility evaluation probes currently
available in the field. According to Professor Taylor "being able to
obtain infrared spectra at nanoscale spatial resolution is a dramatic
development that should provide new insights into the microstructure of
pharmaceutical formulations. This will enable us perform in-depth studies that
enable relationships between microstructure, processing and product performance
to be elucidated."
Reference 1: "Nanoscale Mid-Infrared Imaging of Phase Separation in a
Drug-Polymer Blend", Bernard Van Eerdenbrugh, Micheal Lo, Kevin Kjoller,
Curtis Marcott, and Lynne S. Taylor,
Journal of Pharmaceutical Sciences,
101(6), 2066-2073, (2012).
Publication Date (Web): March 2, 2012 DOI: 10.1002/jps.23099
Reference 2: "Nanoscale Mid-Infrared Evaluation of the Miscibility
Behavior of blends of Dextran or Maltodextrin with
Poly(vinylpyrrolidone)", Bernard Van Eerdenbrugh, Micheal Lo, Kevin
Kjoller, Curtis Marcott, and Lynne S. Taylor,
Molecular Pharmaceutics,
in press.
Publication Date (Web): April 8, 2012 DOI: 10.1021/mp300059zFor further details, please visit
www.anasysinstruments.com
About Anasys Instruments
Anasys Instruments is dedicated to delivering innovative products and solutions
that analyze samples with spatially varying physical and chemical properties at
the micro and nanoscale. Anasys Instruments introduced the nanoTA in 2006 which
pioneered the field of nanoscale thermal property measurement. In 2010, Anasys
Instruments proudly introduced the award-winning breakthrough nanoIR
TM Platform
which pioneered the field of nanoscale IR measurement.
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