in conjunction with Dr. Paolo Macchiarini, [Macciarini, P. et al.
Clinical transplantation of a tissue-engineered airway, Lancet, 372,
2023-2030, (2008)] has developed the InBreath Whole Organ Bioreactor*.
The InBreath is one of the world's first
commercially available bioreactors for tubular organ regeneration. Designed for
tissue engineering and regenerative medicine research applications using
trachea, esophagus, intestines, blood vessels or virtually any hollow organ,
the InBreath is precision engineered for cell seeding and culturing on both
intraluminal and extraluminal surfaces of a tubular matrix.
A
polymer-based culture chamber houses the scaffold and culture medium for the
entire duration of the organ generation procedure.
An
organ scaffold is mounted to the corresponding scaffold holder of appropriate
diameter. Each holder features a reduced diameter central portion which
functions to expose the intraluminal surface of the matrix for cell seeding and
culturing.
Secondary
elements or "paddles" moving with the scaffold holder produce continuous mixing
of the culture medium to increase oxygenation and mass transport. The
cell/scaffold construct is rotated on the holder by a brushless DC motor (0-5
rpm adjustable) which is completely separated from the culture compartment.
A
co-axial conduit links the inner chamber to the external environment through an
interface at the chamber wall. The detachable connection between the motor unit
and the
culture chamber allows the latter to be removed for maintenance
while the motor unit remains stationed in the incubator.
An
external control unit regulates and monitors rotation. Autoclavability, ease of
handling under sterile conditions, reliability and precision ensures full
compatibility of the device with GLP rules.
*For Research Use Only; not for use on humans unless
proper investigational device regulations have been followed.
To receive a copy of the NEW Regenerative
Medicine Catalog, go to
www.harvardapparatus.com
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