As well as exhibiting the FT4 Powder
Rheometer at this year's AAPS Annual Meeting & Exposition (24-27 October
2011; Washington DC), Freeman Technology will present a poster detailing a
comparison of dynamic powder characterisation with traditional tapped density
methods for assessing powder flowability. This highlights the greater
sensitivity of dynamic methods for predicting the impact of consolidation on
flow behaviour, underlining the technique's value in optimizing manufacturing
processes. In addition, in his role as chair of the AAPS PAT (Process
Analytical Technology) focus group, the company's Director of Operations Tim
Freeman, will moderate a sunrise session on Wednesday 26
th October
covering QBD (Quality by Design) and PAT.
Freeman Technology's poster
‘Measuring
more meaningful powder flow properties - the limitations of "Compressibility
Index" data', will be displayed from 1pm - 5pm on 24 October in Hall
C. It includes new data showing that changes in powder flowability resulting
from compaction, as directly measured in dynamic testing, can be an order of
magnitude greater than the changes induced in density by tapping. These
findings highlight the importance of dynamic characterisation in process
related studies, where it can be crucial to understand how compaction
influences in-process performance. Furthermore they provide evidence of
how tapped density measurements can be misleading when seeking to understand
flow behaviour.
As chair of the AAPS PAT focus group,
which primarily resides within the Manufacturing, Science and Engineering
section of the society, Tim Freeman is spearheading efforts to shape the
group as a centre of excellence for this important topic. The sunrise
debate will consider the links between PAT and QbD, their current status within
the pharmaceutical industry and the challenges involved in implementation. In
addition, there will be a PAT FG meeting at the conference on Weds 26
th
Oct, from 12.00 to 1.00. All those interested in PAT are welcome at both events
- for full program details
click here
For information about powder
characterisation go to
www.freemantech.co.uk
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