With the rapid isolation and identification of
verocytotoxigenic strains of Escherichia coli a high priority, Lab M's
Captivate
TM immunomagnetic separation (IMS) technique allows part of the
conventional enrichment to be omitted, helping labs achieve faster
results.
Captivate
TM uses antibody-coated microscopic paramagnetic
particles for the specific immunomagnetic separation of micro-organisms. The
beads have a magnetite core and a ceramic zirconium oxide coating and are
designed for the immunomagnetic separation of target bacteria from enrichment
cultures.
When incubated with a sample, the antibody-coated beads bind
to cell surface antigens forming an antibody-antigen complex between the beads
and the target molecules. Target cells are "captured" and are then separated
from background organisms and interfering materials using a magnetic
concentrator. Non-specifically bound material is removed by washing and beads are
then plated to selective media or subjected to other analyses.
Analagous to selective enrichment, IMS offers greater speed
and can be a less damaging alternative to the use of antibiotics and other
harsh reagents. It is highly effective in enhancing the isolation rates
of target organisms, even from potentially problematic samples. IMS is often
also used in conjunction with other technologies, such as PCR, and can also
provide the ‘capture' front end for automated rapid-detection systems.
www.labm.com
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