AMSBIO Expands Wnt Signaling Pathway Product Portfolio

publication date: Jan 16, 2019
 | 
author/source: AMS Biotechnology (Europe) Ltd

Wingless/Integrated (Wnt) recombinant proteins


AMSBIO has expanded its range of Wingless/Integrated (Wnt) recombinant proteins, stable reporter cell lines, antibodies and ELISA kits to assist researchers in the fields of developmental biology and oncology.

The Wnt family of cysteine-rich secreted polypeptides comprise more than 16 mammalian family members involved in several important cell functions such as cell cell-cell communication, proliferation, migration, polarity, survival and self-renewal. In addition, the Wnt3a signal plays an important role in the ability of organoids to expand. Additionally, loss of activation of Wnt expression is associated with alteration of cell fate, morphogenesis and mitogenesis.

AMSBIO offers a comprehensive range of Wnt human and mouse recombinant proteins in high (85 – 90%) and low (75%) purity. These human recombinant proteins are purified from HEK293 cells while the mouse proteins are expressed in CHO cells. Both are highly suitable for various cell-based assays and treatments. Recombinant Wnt proteins are now also available with a new Wnt stabilizer that can significantly extend the activity of this protein, extending half-life of Wnt3a in serum-free medium to about 24-30 hours (in contrast to half-life of around 2 hours without stabilizer).

High purity HEK293, HCT-116 or SW480 Wnt reporter cell lines are available from AMSBIO all of which have matching controls and can also be ordered as a package in pairs. These stable cell lines have shown particular utility in applications including evaluation of Wnt protein bioactivity or stability and screening of anti-Wnt compounds, antibodies, signal enhancers and to monitor the activity of ß-catenin-based Wnt signal transduction pathway.

For detection of several different Wnt proteins, AMSBIO offers several sensitive and easy-to-use human and mouse ELISA assay kits. AMSBIO also offers a range of polyclonal Wnt antibodies produced in-vivo, suitable for ELISA, IHC and Lateral Flow applications.

 

find out more

more news from amsbio



If you have not logged into the website then please enter your details below.



 

Subscribe to any of our newsletters for the latest on new laboratory products, industry news, case studies and much more!

Newsletters from Lab Bulletin

 

Request your free copies HERE

 

 

 

Popular this Month

Top 10 most popular articles this month

 

 

Today's Picks

 


 

Looking for a Supplier?

Search by company or by product

 


Company Name:

Product:


 

 

 

 

Please note Lab Bulletin does not sell, supply any of the products featured on this website. If you have an enquiry, please use the contact form below the article or company profile and we will send your request to the supplier so that they can contact you directly.

Lab Bulletin is published by newleaf marketing communications ltd.