Channels

 

Special Offers & Promotions

 

 

Latest News

 

 

View Channel

New Products

 

 

View Channel

Video Presentations

 

 

View Channel

Separation Science

 

 

View Channel

Microscopy & Image Analysis

 

 

View Channel

Laboratory Automation & IT Solutions

 

 

View Channel

 

Creative Biolabs Announces Dual Variable Domain Immunoglobulin Service

publication date: Jun 8, 2015
 | 
author/source: Creative Biolabs

With the efforts of its scientists and other staff members, Creative Biolabs announced Dual Variable Domain Immunoglobulin (DVD-Ig) Production Service. This service is able to provide immunoglobulin molecules that simultaneously target two mediators of disease with a single pharmaceutical entity. 

Creative Biolabs logoThe DVD-Ig is an IgG-like molecule, except that each light chain and heavy chain contains two variable domains in tandem through a short peptide linkage instead of one variable domain. As simultaneous blockade of multiple targets may yield better therapeutic efficacy than inhibition of a single target, they were originally designed for the treatment of complex diseases in which multiple mediators contribute to overall disease pathogenesis by distinct or redundant mechanisms.

With years of experience in this field, Creative Biolabs has being professional in providing DVD-Ig molecules of reduced potential immunogenicity, full effector functions and robust serum stability. Their service include the selection of the VD pairing from parental mAbs, the arrangement of the inner/outer orientation of the selected VDs and the determination of the amino acid sequences used to link the VDs. They also offer optimized DVD-Ig molecules which have many desirable properties of a mAb, such as good expression in mammalian cells, easy purification to homogeneity using standard approaches, etc. Unique technology has made it possible for Creative Biolabs to provide DVD-Ig molecules with good drug-like biophysical and pharmacokinetic properties as well as amenability to large-scale manufacturing.


more about the dual variable domain immunoglobulin service


 About Creative Biolabs

Creative Biolabs is a professional biotech related service provider from the USA. It is specialized in providing custom biotechnology and pharmaceutical services that cover the full scope of biotechnology needs of early drug discovery and drug development.


more about Creative Biolabs



 

Subscribe to any of our newsletters for the latest on new laboratory products, industry news, case studies and much more!

Newsletters from Lab Bulletin

 

Request your free copies HERE

 

 

 

Popular this Month

Top 10 most popular articles this month

 

 

Today's Picks

 


 

Looking for a Supplier?

Search by company or by product

 


Company Name:

Product:


 

 

 

 

Please note Lab Bulletin does not sell, supply any of the products featured on this website. If you have an enquiry, please use the contact form below the article or company profile and we will send your request to the supplier so that they can contact you directly.

Lab Bulletin is published by newleaf marketing communications ltd.


 

Media Partners

 

Exhibitions & Events