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With years of advancement and accumulation, Creative BioMart has become a new protein engineering service “portal”. Creative Biomart has strong expertise in de novo gene synthesis that allows us to synthesize complex protein libraries without any dramatic increase in cost

Protein engineering is a new approach. Currently it has been widely used by researchers for the studies, such as protein structure, creation of new material, finding target, function mechanism, combination of new protein with preset features and others. In the future, more detailed knowledge of protein structure and function, as well as advancements in high-throughput technology, may greatly expand the capabilities of protein engineering. Eventually, even unnatural amino acids may be incorporated thanks to the new method that allows the inclusion of novel amino acids in the genetic code.

There are two general strategies for protein engineering, rational design and directed evolution. The protein engineering from Creative Biomart has these features:

Applications

• Optimize solubility
• Evaluate minimal functional-protein size
• Identify functional domains
• Screen for inhibitors
• Map epitopes

Advantages

• More functional variants
• No system-based out-of-frame mutations
• Low ancillary mutation rates—>90% sequence integrity (depending on length of the gene;   unintended mutants will have amino acid substitutions in most cases)
• High success rates—receive all possible truncation variants; library diversity of up to ~40,000

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